{"id":33,"date":"2021-06-07T17:17:10","date_gmt":"2021-06-07T16:17:10","guid":{"rendered":"https:\/\/modsim-pharma.com\/?page_id=33"},"modified":"2021-09-28T09:42:34","modified_gmt":"2021-09-28T08:42:34","slug":"gpcrmodsim","status":"publish","type":"page","link":"https:\/\/modsim-pharma.com\/index.php\/gpcrmodsim\/","title":{"rendered":"GPCR-ModSim"},"content":{"rendered":"\n
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A one-stop package for the optimized modeling and molecular dynamics simulation of GPCRs<\/em>.<\/p>\n<\/div>\n\n\n\n

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GPCR-ModSim <\/strong>is a centralized and easy to use service dedicated to the structural modeling of G Protein-Coupled Receptors (GPCRs). 3D molecular models can be generated from amino acid sequence by homology-modeling techniques, considering different receptor conformations. <\/p>\n\n\n\n

GPCR-ModSim includes PyMemdyn<\/strong>, a stand-alone membrane insertion and molecular dynamics (MD) equilibration protocol, which can be used to refine the generated model or any GPCR structure. <\/p>\n\n\n\n

GPCR ModSim was the best automated protocol to model the structure of the 5-HT2b serotonin receptor in the GPCRdock competition.<\/p>\n\n\n\n

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GPCR-ModSim: A comprehensive web based solution for modeling G-protein coupled receptors<\/a>
M. Esguerra, A. Siretskiy, X. Bello, J. Sallander, H. Guti\u00e9rrez-de-Ter\u00e1n, Nucleic Acids Research<\/em> 2016<\/strong>, 44 <\/em>(W1), W455\u2013W462.<\/p>\n","protected":false},"excerpt":{"rendered":"

A one-stop package for the optimized modeling and molecular dynamics simulation of GPCRs. GPCR-ModSim is a centralized and easy to use service dedicated to the structural modeling of G Protein-Coupled Receptors (GPCRs). 3D molecular models can be generated from amino acid sequence by homology-modeling techniques, considering different receptor conformations. GPCR-ModSim includes PyMemdyn, a stand-alone membrane… Read More »GPCR-ModSim<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":486,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"class_list":["post-33","page","type-page","status-publish","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/modsim-pharma.com\/index.php\/wp-json\/wp\/v2\/pages\/33","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/modsim-pharma.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/modsim-pharma.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/modsim-pharma.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/modsim-pharma.com\/index.php\/wp-json\/wp\/v2\/comments?post=33"}],"version-history":[{"count":17,"href":"https:\/\/modsim-pharma.com\/index.php\/wp-json\/wp\/v2\/pages\/33\/revisions"}],"predecessor-version":[{"id":782,"href":"https:\/\/modsim-pharma.com\/index.php\/wp-json\/wp\/v2\/pages\/33\/revisions\/782"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/modsim-pharma.com\/index.php\/wp-json\/wp\/v2\/media\/486"}],"wp:attachment":[{"href":"https:\/\/modsim-pharma.com\/index.php\/wp-json\/wp\/v2\/media?parent=33"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}