{"id":96,"date":"2021-06-14T08:14:34","date_gmt":"2021-06-14T07:14:34","guid":{"rendered":"https:\/\/modsim-pharma.com\/?page_id=96"},"modified":"2021-09-28T09:00:25","modified_gmt":"2021-09-28T08:00:25","slug":"gpcr-workflow","status":"publish","type":"page","link":"https:\/\/modsim-pharma.com\/index.php\/gpcr-workflow\/","title":{"rendered":"GPCR workflow"},"content":{"rendered":"\n<div class=\"wp-block-columns are-vertically-aligned-center is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:200%\">\n<p><em>From the sequence of a GPCR target to the lead optimization of chemical modulators<\/em>.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"554\" height=\"561\" src=\"https:\/\/modsim-pharma.com\/wp-content\/uploads\/2021\/09\/GPCR-workflow_icon.png\" alt=\"\" class=\"wp-image-765\" srcset=\"https:\/\/modsim-pharma.com\/wp-content\/uploads\/2021\/09\/GPCR-workflow_icon.png 554w, https:\/\/modsim-pharma.com\/wp-content\/uploads\/2021\/09\/GPCR-workflow_icon-296x300.png 296w\" sizes=\"auto, (max-width: 554px) 100vw, 554px\" \/><\/figure>\n<\/div>\n<\/div>\n\n\n\n<p>MODSIM offers a variety of products, which can be efficiently combined to develop new compounds. The below image shows an example of our workflow applied to GPCRs. <\/p>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"478\" src=\"https:\/\/modsim-pharma.com\/wp-content\/uploads\/2021\/08\/MODSIM-workflow-1024x478.png\" alt=\"\" class=\"wp-image-625\" srcset=\"https:\/\/modsim-pharma.com\/wp-content\/uploads\/2021\/08\/MODSIM-workflow-1024x478.png 1024w, https:\/\/modsim-pharma.com\/wp-content\/uploads\/2021\/08\/MODSIM-workflow-300x140.png 300w, https:\/\/modsim-pharma.com\/wp-content\/uploads\/2021\/08\/MODSIM-workflow-768x358.png 768w, https:\/\/modsim-pharma.com\/wp-content\/uploads\/2021\/08\/MODSIM-workflow-1536x717.png 1536w, https:\/\/modsim-pharma.com\/wp-content\/uploads\/2021\/08\/MODSIM-workflow-2048x956.png 2048w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p>A published example of the workflow:<\/p>\n\n\n\n<p><a rel=\"noreferrer noopener\" href=\"https:\/\/www.mdpi.com\/236672\" target=\"_blank\">Structure-based design of potent and selective ligands at the four adenosine receptors<\/a><br>W. Jespers, A. Oliveira, R. Prieto-D\u00edaz, M. Majellaro, J. \u00c5qvist, E. Sotelo, H. Guti\u00e9rrez-de-Ter\u00e1n, <em>Molecules <\/em><strong>2017<\/strong>, <em>22<\/em> (11), 1945.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>From the sequence of a GPCR target to the lead optimization of chemical modulators. MODSIM offers a variety of products, which can be efficiently combined to develop new compounds. The below image shows an example of our workflow applied to GPCRs. A published example of the workflow: Structure-based design of potent and selective ligands at&hellip;&nbsp;<a href=\"https:\/\/modsim-pharma.com\/index.php\/gpcr-workflow\/\" rel=\"bookmark\">Read More &raquo;<span class=\"screen-reader-text\">GPCR workflow<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"","neve_meta_content_width":0,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","footnotes":""},"class_list":["post-96","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/modsim-pharma.com\/index.php\/wp-json\/wp\/v2\/pages\/96","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/modsim-pharma.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/modsim-pharma.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/modsim-pharma.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/modsim-pharma.com\/index.php\/wp-json\/wp\/v2\/comments?post=96"}],"version-history":[{"count":10,"href":"https:\/\/modsim-pharma.com\/index.php\/wp-json\/wp\/v2\/pages\/96\/revisions"}],"predecessor-version":[{"id":767,"href":"https:\/\/modsim-pharma.com\/index.php\/wp-json\/wp\/v2\/pages\/96\/revisions\/767"}],"wp:attachment":[{"href":"https:\/\/modsim-pharma.com\/index.php\/wp-json\/wp\/v2\/media?parent=96"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}